Adverse pregnancy outcomes as a risk factor for new-onset metabolic dysfunction-associated steatotic liver disease in postpartum women: A nationwide study

Young Mi Jung; Seung Mi Lee; Wonyoung Wi; Min-Jeong Oh; Joong Shin Park; Geum Joon Cho; Won Kim

JHEP Reports (Apr 2024)

Adverse pregnancy outcomes as a risk factor for new-onset metabolic dysfunction-associated steatotic liver disease in postpartum women: A nationwide study

Young Mi Jung,
Seung Mi Lee,
Wonyoung Wi,
Min-Jeong Oh,
Joong Shin Park,
Geum Joon Cho,
Won Kim

Affiliations

Young Mi Jung: Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea
Seung Mi Lee: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea; Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea; Innovative Medical Technology Research Institute, Seoul National University Hospital, Seoul, Korea; Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Korea
Wonyoung Wi: Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea
Min-Jeong Oh: Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea
Joong Shin Park: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea; Corresponding authors. Addresses: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea. Tel.: +82-2-2072-3199; Fax: +82-2-762-3599 (J.S. Park); Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea. Tel.: +82-2-2626-3145; Fax: +82-2-838-1560 (G.J. Cho); Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center 20, Boramae-ro 5-gil, Dongjak-gu, Seoul 07061, Korea. Tel.: +82-2-870-2233; Fax: +82-2-831-2826 (W. Kim).
Geum Joon Cho: Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea; Corresponding authors. Addresses: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea. Tel.: +82-2-2072-3199; Fax: +82-2-762-3599 (J.S. Park); Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea. Tel.: +82-2-2626-3145; Fax: +82-2-838-1560 (G.J. Cho); Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center 20, Boramae-ro 5-gil, Dongjak-gu, Seoul 07061, Korea. Tel.: +82-2-870-2233; Fax: +82-2-831-2826 (W. Kim).
Won Kim: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea; Corresponding authors. Addresses: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea. Tel.: +82-2-2072-3199; Fax: +82-2-762-3599 (J.S. Park); Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea. Tel.: +82-2-2626-3145; Fax: +82-2-838-1560 (G.J. Cho); Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center 20, Boramae-ro 5-gil, Dongjak-gu, Seoul 07061, Korea. Tel.: +82-2-870-2233; Fax: +82-2-831-2826 (W. Kim).

Journal volume & issue: Vol. 6, no. 4
p. 101033

Abstract

Read online

Background & Aims: Adverse pregnancy outcomes (APOs) can worsen cardiometabolic risk factors in women, raising their likelihood of developing cardiometabolic diseases at a young age after their initial pregnancy. Nevertheless, there are limited data on the risk of newly developing metabolic dysfunction-associated steatotic liver disease (MASLD) in women who have had APOs. This study aimed to evaluate the risk of new-onset MASLD after experiencing APOs. Methods: Singleton pregnant women who underwent national health screenings 1 year before pregnancy and 1 year after delivery were included in this study. APOs were defined as the presence of at least one of the followings: hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), preterm birth, low birth weight, and placental abruption. The primary outcome was new-onset MASLD based on the presence of APOs. Results: Among 80,037 study participants, 9,320 (11.6%) experienced APOs during pregnancy. Women who experienced APOs had an increased risk of developing new-onset MASLD after delivery even after adjustments for various covariates (adjusted odds ratio [OR] 1.58, 95% CI 1.45–1.72). In particular, women who experienced either HDP or GDM showed a significantly increased risk of developing new-onset MASLD (adjusted OR 2.20, 95% CI 1.81–2.67, for HDP and adjusted OR 1.83, 95% CI 1.65–2.03, for GDM). Moreover, there was a tendency toward an increased risk of new-onset MASLD according to the number of APOs (p <0.001 for trend of odds). Conclusions: APOs were associated with the risk of new-onset MASLD after delivery. Specifically, only HDP or GDM were identified as risk factors for new-onset MASLD. Impact and implications: This nationwide cohort study confirms that postpartum women with a history of adverse pregnancy outcomes (APOs) are at an increased risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD). These findings may bring us one step closer to understanding the exact mechanisms underlying such an important association between prior APOs and cardiovascular disease (CVD) risk among postpartum women. This bidirectional association between APOs and MASLD highlights the importance of considering pregnancy history in assessing CVD risk in women. It suggests a need for closer monitoring and lifestyle interventions for women with a history of APOs to reduce the risk of MASLD and subsequent CVD complications.

Published in JHEP Reports

ISSN: 2589-5559 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://www.journals.elsevier.com/jhep-reports

About the journal

Abstract

Keywords