Nature Communications (Mar 2021)

Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains

  • Lijin K. Gopi,
  • Benjamin L. Kidder

DOI
https://doi.org/10.1038/s41467-021-21707-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 20

Abstract

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The NCI-60 cancer cell line panel covers multiple cancer types but has not been extensively investigated at the epigenetic level. Here, the authors present H3K4me3, H3K27ac, H3K9me3, and H4K20me3 ChIP-Seq analysis of the cell lines, and describe features of chromatin states and integrative analyses of expression, epigenetic and genetic mutation data.