Spinal polyostotic fibrous dysplasia in two adults: Does only biopsy unravel the mystery?

Abstract

Polyostotic fibrous dysplasia is a rare non-inheritable genetic disease due to mutation in GNAS gene. Here we present two adults who were accidentally detected lytic lesions in spine and after extensive evaluation for malignancies; was diagnosed on biopsy. Current concept of the disease and management is discussed.

Keywords

• Fibrous dysplasia
• McCune albright syndrome
• thyrotoxicosis