Nature Communications (Jul 2017)

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

  • Yoshiharu Muto,
  • Masaaki Nishiyama,
  • Akihiro Nita,
  • Toshiro Moroishi,
  • Keiichi I. Nakayama

DOI
https://doi.org/10.1038/ncomms16114
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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The iron-regulated F-box protein FBXL5 regulates iron homeostasis by mediating the degradation of iron regulatory protein 2 (IRP2). Here the authors show that FBXL5 and its regulation of IRP2 are required for HSC self-renewal and reconstitution capability.