Emergence of Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus within 48 Hours

Abstract

An oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus evolved and emerged from zero to 52% of detectable virus within 48 hours of a patient’s exposure to oseltamivir. Phylogenetic analysis and data gathered by pyrosequencing and cloning directly on clinical samples suggest that the mutant emerged de novo.

Keywords

• Influenza
• pandemic (H1N1) 2009
• viruses
• oseltamivir
• antimicrobial resistance
• Singapore