Frontiers in Cardiovascular Medicine (Aug 2021)

The Brain–Heart Link: A Case Report of a Critically Located Multiple Sclerosis Lesion in the Brainstem Leading to Recurrent Takotsubo Syndrome

  • Florentijn Risseeuw,
  • Pegah Masrori,
  • Ingrid Baar,
  • Ingrid Baar,
  • Simon Nicolay,
  • Constantijn Franssen,
  • Constantijn Franssen,
  • Barbara Willekens,
  • Barbara Willekens

DOI
https://doi.org/10.3389/fcvm.2021.674118
Journal volume & issue
Vol. 8

Abstract

Read online

Various central nervous system (CNS) diseases, including neurovascular and neuroinflammatory diseases, can lead to stress cardiomyopathy, also known as Takotsubo syndrome (TTS). We present a case of a 69-year-old woman with cardiovascular comorbidities, suffering from repeated episodes of TTS and respiratory failure due to a critical lesion in the brainstem, leading to a diagnosis of multiple sclerosis (MS). Despite aggressive treatment, intractable and recurrent symptoms in our patient occurred. Repeated bouts of autonomic dysfunction and respiratory failure ultimately led to installment of palliative care and the patient passing away. TTS should raise suspicion for underlying neurological diseases. Thorough questioning of previous neurological symptoms and extensive neurological workup is warranted. MS should be considered as a trigger of TTS also in elderly patients with cardiovascular risk factors.

Keywords