Anti-relapse neurons in the infralimbic cortex of rats drive relapse-suppression by drug omission cues

Amanda Laque; Genna L. De Ness; Grant E. Wagner; Hermina Nedelescu; Ayla Carroll; Debbie Watry; Tony M. Kerr; Eisuke Koya; Bruce T. Hope; Friedbert Weiss; Greg I. Elmer; Nobuyoshi Suto

doi:10.1038/s41467-019-11799-1

Nature Communications (Sep 2019)

Anti-relapse neurons in the infralimbic cortex of rats drive relapse-suppression by drug omission cues

Amanda Laque,
Genna L. De Ness,
Grant E. Wagner,
Hermina Nedelescu,
Ayla Carroll,
Debbie Watry,
Tony M. Kerr,
Eisuke Koya,
Bruce T. Hope,
Friedbert Weiss,
Greg I. Elmer,
Nobuyoshi Suto

Affiliations

Amanda Laque: Department of Neuroscience, The Scripps Research Institute
Genna L. De Ness: Department of Neuroscience, The Scripps Research Institute
Grant E. Wagner: Department of Neuroscience, The Scripps Research Institute
Hermina Nedelescu: Department of Neuroscience, The Scripps Research Institute
Ayla Carroll: Department of Neuroscience, The Scripps Research Institute
Debbie Watry: Department of Neuroscience, The Scripps Research Institute
Tony M. Kerr: Department of Neuroscience, The Scripps Research Institute
Eisuke Koya: Sussex Neuroscience, School of Psychology, University of Sussex
Bruce T. Hope: Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS
Friedbert Weiss: Department of Neuroscience, The Scripps Research Institute
Greg I. Elmer: Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine
Nobuyoshi Suto: Department of Neuroscience, The Scripps Research Institute

DOI: https://doi.org/10.1038/s41467-019-11799-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Drug addiction is a chronic disorder and many sufferers experience relapses even after a period of successful abstinence. Here, the authors reveal a subset of neurons in the rat infralimbic cortex that suppresses relapse into cocaine or alcohol use by responding to drug-omission cues.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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