Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-<i>Staphylococcus aureus</i> Agents

Rawan Alnufaie; Hansa Raj KC; Nickolas Alsup; Jedidiah Whitt; Steven Andrew Chambers; David Gilmore; Mohammad A. Alam

doi:10.3390/molecules25122758

Molecules (Jun 2020)

Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-<i>Staphylococcus aureus</i> Agents

Rawan Alnufaie,
Hansa Raj KC,
Nickolas Alsup,
Jedidiah Whitt,
Steven Andrew Chambers,
David Gilmore,
Mohammad A. Alam

Affiliations

Rawan Alnufaie: Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, USA
Hansa Raj KC: Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, USA
Nickolas Alsup: Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, USA
Jedidiah Whitt: Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, USA
Steven Andrew Chambers: Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, USA
David Gilmore: Department of Biological Sciences, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, USA
Mohammad A. Alam: Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR 72467, USA

DOI: https://doi.org/10.3390/molecules25122758
Journal volume & issue: Vol. 25, no. 12
p. 2758

Abstract

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In this paper, synthesis and antimicrobial studies of 31 novel coumarin-substituted pyrazole derivatives are reported. Some of these compounds have shown potent activity against methicillin-resistant Staphylococcus aureus (MRSA) with minimum inhibitory concentration (MIC) as low as 3.125 µg/mL. These molecules are equally potent at inhibiting the development of MRSA biofilm and the destruction of preformed biofilm. These results are very significant as MRSA strains have emerged as one of the most menacing pathogens of humans and this bacterium is bypassing HIV in terms of fatality rate.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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