PLoS ONE (Jan 2015)

The Relationship between Extensively Drug-Resistant Tuberculosis and Multidrug-Resistant Gram-Negative Bacilli.

  • Jiang-Nan Zhao,
  • Xian-Xin Zhang,
  • Xiao-Chun He,
  • Guo-Ru Yang,
  • Xiao-Qi Zhang,
  • Huai-Chen Li

DOI
https://doi.org/10.1371/journal.pone.0134998
Journal volume & issue
Vol. 10, no. 7
p. e0134998

Abstract

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ObjectiveThe relationship between extensively drug-resistant tuberculosis (XDR-TB) and multidrug-resistant Gram-negative bacilli (MDR-GNB) is unclear. Identification of the relationship between XDR-TB and MDR-GNB would have important implications for patient care.MethodsWe conducted a retrospective study reviewing the records of patients admitted with a confirmed pulmonary TB from 2011 to 2014. To identify the relationship between XDR-TB and MDR-GNB, univariable comparison and multivariable logistic regression were performed.ResultsAmong 2962 pulmonary TB patients, 45(1.5%) patients had a diagnosis of XDR-TB. A total of 165 MDR-GNB strains were detected in 143 (4.8%) pulmonary TB patients. XDR-TB patients had a significantly higher occurrence of MDR-GNB than non-XDR-TB patients (24.4% vs. 4.5%; PConclusionsPatients with XDR-TB have a significantly higher risk of being affected by MDR-GNB pathogen. The underlying mechanism association warrant further studies.