In mouse chronic pancreatitis CD25+FOXP3+ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response

Juliane Glaubitz; Anika Wilden; Janine Golchert; Georg Homuth; Uwe Völker; Barbara M. Bröker; Thomas Thiele; Markus M. Lerch; Julia Mayerle; Ali A. Aghdassi; Frank U. Weiss; Matthias Sendler

doi:10.1038/s41467-022-32195-2

Nature Communications (Aug 2022)

In mouse chronic pancreatitis CD25+FOXP3+ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response

Juliane Glaubitz,
Anika Wilden,
Janine Golchert,
Georg Homuth,
Uwe Völker,
Barbara M. Bröker,
Thomas Thiele,
Markus M. Lerch,
Julia Mayerle,
Ali A. Aghdassi,
Frank U. Weiss,
Matthias Sendler

Affiliations

Juliane Glaubitz: Department of Medicine A, University Medicine, University of Greifswald
Anika Wilden: Department of Medicine A, University Medicine, University of Greifswald
Janine Golchert: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
Georg Homuth: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
Uwe Völker: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
Barbara M. Bröker: Department of Immunology, Institute of Immunology and Transfusion Medicine, University Medicine
Thomas Thiele: Department of Transfusion Medicine, Institute of Immunology and Transfusion Medicine, University Medicine
Markus M. Lerch: Department of Medicine A, University Medicine, University of Greifswald
Julia Mayerle: Department of Medicine A, University Medicine, University of Greifswald
Ali A. Aghdassi: Department of Medicine A, University Medicine, University of Greifswald
Frank U. Weiss: Department of Medicine A, University Medicine, University of Greifswald
Matthias Sendler: Department of Medicine A, University Medicine, University of Greifswald

DOI: https://doi.org/10.1038/s41467-022-32195-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 20

Abstract

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The function of T regulatory cells in the tissue fibrosis in chronic pancreatitis is not fully understood. Here the authors use a mouse model of chronic pancreatitis to show that Treg cells reduce IL-4 mediated chronic inflammation in the pancreas associated with M2-like macrophages in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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