Frontiers in Aging (Jul 2022)

Functional role of miR-34a in diabetes and frailty

  • Pasquale Mone,
  • Pasquale Mone,
  • Antonio de Donato,
  • Fahimeh Varzideh,
  • Urna Kansakar,
  • Stanislovas S. Jankauskas,
  • Antonella Pansini,
  • Gaetano Santulli,
  • Gaetano Santulli

DOI
https://doi.org/10.3389/fragi.2022.949924
Journal volume & issue
Vol. 3

Abstract

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Emerging evidence has shown that microRNAs (miRNAs) play critical role in the pathogenesis of several disorders. In the present minireview, we focus our attention on the functional role of a specific miRNA, namely miR-34a, in the pathophysiology of frailty and diabetes mellitus. Based on the current literature, we speculate that this miRNA may serve as a potential biomarker of frailty in diabetic older adults. Additionally, its actions on oxidative stress might represent a druggable target to obtain new potentials treatments.

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