Nature Communications (Oct 2017)
TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p
- Jonathan Berrout,
- Eleni Kyriakopoulou,
- Lavanya Moparthi,
- Alexandra S. Hogea,
- Liza Berrout,
- Cristina Ivan,
- Mihaela Lorger,
- John Boyle,
- Chris Peers,
- Stephen Muench,
- Jacobo Elies Gomez,
- Xin Hu,
- Carolyn Hurst,
- Thomas Hall,
- Sujanitha Umamaheswaran,
- Laura Wesley,
- Mihai Gagea,
- Michael Shires,
- Iain Manfield,
- Margaret A. Knowles,
- Simon Davies,
- Klaus Suhling,
- Yurema Teijeiro Gonzalez,
- Neil Carragher,
- Kenneth Macleod,
- N. Joan Abbott,
- George A. Calin,
- Nikita Gamper,
- Peter M. Zygmunt,
- Zahra Timsah
Affiliations
- Jonathan Berrout
- School of Molecular and Cellular Biology, University of Leeds
- Eleni Kyriakopoulou
- School of Molecular and Cellular Biology, University of Leeds
- Lavanya Moparthi
- Division of Clinical Chemistry and Pharmacology, Lund University
- Alexandra S. Hogea
- School of Biomedical Sciences, University of Leeds
- Liza Berrout
- The University of Texas at Brownsville
- Cristina Ivan
- Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
- Mihaela Lorger
- Leeds Institute of Cancer and Pathology, Wellcome Trust Brenner Building, St James’s University Hospital
- John Boyle
- Faculty of Medicine and Health, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds
- Chris Peers
- Faculty of Medicine and Health, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds
- Stephen Muench
- School of Biomedical Sciences, University of Leeds
- Jacobo Elies Gomez
- Faculty of Medicine and Health, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds
- Xin Hu
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Carolyn Hurst
- Faculty of Medicine and Health, Leeds Institute of Cancer and Pathology, University of Leeds
- Thomas Hall
- School of Molecular and Cellular Biology, University of Leeds
- Sujanitha Umamaheswaran
- Centre for Biotechnology, Anna University
- Laura Wesley
- School of Molecular and Cellular Biology, University of Leeds
- Mihai Gagea
- Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Unit 63
- Michael Shires
- Section of Pathology and Tumor Biology, Leeds Institute of Cancer and Pathology, Wellcome Trust Brenner Building, St James’s University Hospital
- Iain Manfield
- School of Molecular and Cellular Biology, University of Leeds
- Margaret A. Knowles
- Faculty of Medicine and Health, Leeds Institute of Cancer and Pathology, University of Leeds
- Simon Davies
- School of Biomedical Sciences, University of Leeds
- Klaus Suhling
- Department of Physics, King’s College London
- Yurema Teijeiro Gonzalez
- Department of Physics, King’s College London
- Neil Carragher
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Kenneth Macleod
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh
- N. Joan Abbott
- Institute of Pharmaceutical Science, Franklin-Wilkins Building, King’s College London
- George A. Calin
- Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center
- Nikita Gamper
- School of Biomedical Sciences, University of Leeds
- Peter M. Zygmunt
- Division of Clinical Chemistry and Pharmacology, Lund University
- Zahra Timsah
- School of Molecular and Cellular Biology, University of Leeds
- DOI
- https://doi.org/10.1038/s41467-017-00983-w
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
TRPA1 has been reported to contribute lung cancer adenocarcinoma (LUAD), but the mechanisms are unclear. Here the authors propose that TRPA1/FGFR2 interaction is functional in LUAD and show that astrocytes oppose brain metastasis by mediating the downregulation of TRPA1 through exosome-delivered miRNA-142-3p.
