Stability of SARS-CoV-2 Spike G614 Variant Surpasses That of the D614 Variant after Cold Storage

Sheng-Yu Huang; Yu-An Kung; Peng-Nien Huang; Sheng-Yun Chang; Yu-Nong Gong; Yi-Ju Han; Huan-Jung Chiang; Kuan-Ting Liu; Kuo-Ming Lee; Chia-Yu Chang; Chia-Ching Chang; Chung-Guei Huang; Shin-Ru Shih

doi:10.1128/mSphere.00104-21

mSphere (Apr 2021)

Stability of SARS-CoV-2 Spike G614 Variant Surpasses That of the D614 Variant after Cold Storage

Sheng-Yu Huang,
Yu-An Kung,
Peng-Nien Huang,
Sheng-Yun Chang,
Yu-Nong Gong,
Yi-Ju Han,
Huan-Jung Chiang,
Kuan-Ting Liu,
Kuo-Ming Lee,
Chia-Yu Chang,
Chia-Ching Chang,
Chung-Guei Huang,
Shin-Ru Shih

Affiliations

Sheng-Yu Huang: ORCiD; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Yu-An Kung: Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Peng-Nien Huang: Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Sheng-Yun Chang: Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Yu-Nong Gong: ORCiD; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Yi-Ju Han: Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Huan-Jung Chiang: Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Kuan-Ting Liu: Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Kuo-Ming Lee: ORCiD; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Chia-Yu Chang: Department of Biological Science and Technology, College of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan
Chia-Ching Chang: Department of Biological Science and Technology, College of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan
Chung-Guei Huang: Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Shin-Ru Shih: ORCiD; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan

DOI: https://doi.org/10.1128/mSphere.00104-21
Journal volume & issue: Vol. 6, no. 2

Abstract

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It has been observed that variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more stable and infectious after storage at −20°C than at 4°C. A SARS-CoV-2 S-D614G variant is currently the most dominant variant in circulation and is associated with enhanced infectivity.

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

About the journal