Structure of human Cdc45 and implications for CMG helicase function

Aline C. Simon; Vincenzo Sannino; Vincenzo Costanzo; Luca Pellegrini

doi:10.1038/ncomms11638

Nature Communications (May 2016)

Structure of human Cdc45 and implications for CMG helicase function

Aline C. Simon,
Vincenzo Sannino,
Vincenzo Costanzo,
Luca Pellegrini

Affiliations

Aline C. Simon: Department of Biochemistry, University of Cambridge
Vincenzo Sannino: DNA Metabolism Laboratory, FIRC Institute of Molecular Oncology Foundation
Vincenzo Costanzo: DNA Metabolism Laboratory, FIRC Institute of Molecular Oncology Foundation
Luca Pellegrini: Department of Biochemistry, University of Cambridge

DOI: https://doi.org/10.1038/ncomms11638
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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The cell cycle division protein Cdc45 is required for genome duplication in eukaryotes. Here, the authors determine the crystal structure of human Cdc45 and combine it with functional data to improve our understanding of its role in DNA replication.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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