Mesenchymal stem cells for treatment of steroid-resistant acute rejection after liver transplantation

Yingcai Zhang; Shihui Li; Guoying Wang; Yanwen Peng; Qi Zhang; Hua Li; Jian Zhang; Genshu Wang; Shuhong Yi; Xiaoyong Chen; Andy Peng Xiang; Yang Yang; Guihua Chen

Liver Research (Sep 2017)

Mesenchymal stem cells for treatment of steroid-resistant acute rejection after liver transplantation

Yingcai Zhang,
Shihui Li,
Guoying Wang,
Yanwen Peng,
Qi Zhang,
Hua Li,
Jian Zhang,
Genshu Wang,
Shuhong Yi,
Xiaoyong Chen,
Andy Peng Xiang,
Yang Yang,
Guihua Chen

Affiliations

Yingcai Zhang: Department of Hepatic Surgery, Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, Guangzhou, China
Shihui Li: Department of Hepatic Surgery, Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, Guangzhou, China
Guoying Wang: Department of Hepatic Surgery, Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, Guangzhou, China
Yanwen Peng: Cell-Gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Qi Zhang: Department of Hepatic Surgery, Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, Guangzhou, China; Cell-Gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Hua Li: Department of Hepatic Surgery, Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, Guangzhou, China
Jian Zhang: Department of Hepatic Surgery, Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, Guangzhou, China
Genshu Wang: Department of Hepatic Surgery, Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, Guangzhou, China
Shuhong Yi: Department of Hepatic Surgery, Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, Guangzhou, China
Xiaoyong Chen: Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, China
Andy Peng Xiang: Cell-Gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, China
Yang Yang: Department of Hepatic Surgery, Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, Guangzhou, China; Corresponding authors. Department of Hepatic Surgery, Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, Guangzhou, China.
Guihua Chen: Department of Hepatic Surgery, Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, Guangzhou, China; Corresponding authors. Department of Hepatic Surgery, Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, Guangzhou, China.

Journal volume & issue: Vol. 1, no. 2
pp. 140 – 145

Abstract

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A patient with steroid-resistant acute rejection 50 days after ABO-compatible orthotopic liver transplantation (LT) received regular infusion of allogeneic mesenchymal stem cells (MSCs) after three sessions of steroid pulse therapy which failed to control the pathogenetic condition as shown by biopsy. Liver function improved gradually after intravenous injection of MSCs once weekly for 10 weeks (as confirmed by biopsy) and remained stable under administration of conventional immunosuppressive agents. There was no evidence of neoplasms 5 years after treatment. MSCs infusion appears to successfully reverse resistance to immunosuppressive agents and may be a useful treatment for post-liver transplant steroid-resistant rejection. Keywords: Mesenchymal stem cells (MSCs), Liver transplantation (LT), Steroid-resistant acute rejection, Immunoregulation

Published in Liver Research

ISSN: 2096-2878 (Print); 2542-5684 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://www.keaipublishing.com/en/journals/liver-research/

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