Lasianosides F–I: A New Iridoid and Three New Bis-Iridoid Glycosides from the Leaves of <i>Lasianthus verticillatus</i> (Lour.) Merr.

Gadah Abdulaziz Al-Hamoud; Raha Saud Orfali; Yoshio Takeda; Sachiko Sugimoto; Yoshi Yamano; Nawal M. Al Musayeib; Omer Ibrahim Fantoukh; Musarat Amina; Hideaki Otsuka; Katsuyoshi Matsunami

doi:10.3390/molecules25122798

Molecules (Jun 2020)

Lasianosides F–I: A New Iridoid and Three New Bis-Iridoid Glycosides from the Leaves of <i>Lasianthus verticillatus</i> (Lour.) Merr.

Gadah Abdulaziz Al-Hamoud,
Raha Saud Orfali,
Yoshio Takeda,
Sachiko Sugimoto,
Yoshi Yamano,
Nawal M. Al Musayeib,
Omer Ibrahim Fantoukh,
Musarat Amina,
Hideaki Otsuka,
Katsuyoshi Matsunami

Affiliations

Gadah Abdulaziz Al-Hamoud: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia
Raha Saud Orfali: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia
Yoshio Takeda: Faculty of Integrated Arts and Sciences, The University of Tokushima, 1-1 Minamijosanjima-Cho, Tokushima 770-8502, Japan
Sachiko Sugimoto: Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Yoshi Yamano: Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Nawal M. Al Musayeib: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia
Omer Ibrahim Fantoukh: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia
Musarat Amina: Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia
Hideaki Otsuka: Faculty of Pharmacy, Yasuda Women’s University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima 731-0153, Japan
Katsuyoshi Matsunami: Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan

DOI: https://doi.org/10.3390/molecules25122798
Journal volume & issue: Vol. 25, no. 12
p. 2798

Abstract

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A series of iridoid glycosides were isolated from the leaves of Lasianthus verticillatus (Lour.) Merr., belonging to family Rubiaceae. A new iridoid glycoside, lasianoside F (1), and three new bis-iridoid glycosides, lasianosides G–I (2–4), together with four known compounds (5–8) were isolated. The structures were established by spectroscopic methods, including 1D and 2D NMR experiments (1H, 13C, DEPT, COSY, HSQC, HMBC, and NOESY) in combination with HR-ESI-MS and CD spectra.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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