Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses

Gabriela Alvarado; Wilhelm Salmen; Khalil Ettayebi; Liya Hu; Banumathi Sankaran; Mary K. Estes; B. V. Venkataram Prasad; James E. Crowe

doi:10.1038/s41467-021-24649-w

Nature Communications (Jul 2021)

Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses

Gabriela Alvarado,
Wilhelm Salmen,
Khalil Ettayebi,
Liya Hu,
Banumathi Sankaran,
Mary K. Estes,
B. V. Venkataram Prasad,
James E. Crowe

Affiliations

Gabriela Alvarado: Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center
Wilhelm Salmen: Department of Molecular Virology and Microbiology, Baylor College of Medicine
Khalil Ettayebi: Department of Molecular Virology and Microbiology, Baylor College of Medicine
Liya Hu: The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine
Banumathi Sankaran: Berkeley Center for Structural Biology, Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley Laboratory
Mary K. Estes: Department of Molecular Virology and Microbiology, Baylor College of Medicine
B. V. Venkataram Prasad: Department of Molecular Virology and Microbiology, Baylor College of Medicine
James E. Crowe: Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center

DOI: https://doi.org/10.1038/s41467-021-24649-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Noroviruses can cause gastroenteritis and there is currently no licensed vaccine or specific treatment available. Here, the authors isolate human monoclonal antibodies and characterize one antibody (NORO-320) with broad reactivity to genogroup I and II noroviruses.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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