D-penicillamine induced degenerative dermopathy

Abstract

D-penicillamine interferes with elastin and collagen metabolism and produces several cutaneous and multi-systemic side-effects. We present two cases of Wilson′s disease who on long-term penicillamine therapy developed drug-induced degenerative dermopathy manifesting as skin fragility over pressure sites and cutis laxa-like changes.

Keywords

• Degenerative dermopathy
• penicillamine
• chronic therapy