Nature Communications (Mar 2021)

Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells

  • P. A. Louwe,
  • L. Badiola Gomez,
  • H. Webster,
  • G. Perona-Wright,
  • C. C. Bain,
  • S. J. Forbes,
  • S. J. Jenkins

DOI
https://doi.org/10.1038/s41467-021-21778-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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The peritoneal cavity is a complicated myeloid niche containing a mixed population of resident macrophages and infiltrating cells that are responsive to inflammatory cues. Here the authors trace the fate of these infiltrating macrophages, their conversion to resident cells and how this is altered by the local inflammatory state over time.