Nature Communications (Nov 2022)
pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation
- Olga Boix,
- Marion Martinez,
- Santiago Vidal,
- Marta Giménez-Alejandre,
- Lluís Palenzuela,
- Laura Lorenzo-Sanz,
- Laura Quevedo,
- Olivier Moscoso,
- Jorge Ruiz-Orera,
- Pilar Ximénez-Embún,
- Nikaoly Ciriaco,
- Paolo Nuciforo,
- Camille Stephan-Otto Attolini,
- M. Mar Albà,
- Javier Muñoz,
- Tian V. Tian,
- Ignacio Varela,
- Ana Vivancos,
- Santiago Ramón y Cajal,
- Purificación Muñoz,
- Carmen Rivas,
- María Abad
Affiliations
- Olga Boix
- Cellular Plasticity and Cancer Group, Vall d’Hebron Institute of Oncology (VHIO)
- Marion Martinez
- Cellular Plasticity and Cancer Group, Vall d’Hebron Institute of Oncology (VHIO)
- Santiago Vidal
- Centro de Investigación en Medicina Molecular (CIMUS), Universidad de Santiago de Compostela and Instituto de Investigaciones Sanitarias (IDIS)
- Marta Giménez-Alejandre
- Cellular Plasticity and Cancer Group, Vall d’Hebron Institute of Oncology (VHIO)
- Lluís Palenzuela
- Cellular Plasticity and Cancer Group, Vall d’Hebron Institute of Oncology (VHIO)
- Laura Lorenzo-Sanz
- Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL)
- Laura Quevedo
- Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria - CSIC
- Olivier Moscoso
- Department of Pathology, Vall d’Hebron University Hospital, Translational Molecular Pathology, Vall d’Hebron Institute of Research (VHIR), Universitat Autònoma de Barcelona and Spanish Biomedical Research Network Centre in Oncology (CIBERONC)
- Jorge Ruiz-Orera
- Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
- Pilar Ximénez-Embún
- Proteomics Unit, Spanish National Cancer Research Centre (CNIO)
- Nikaoly Ciriaco
- Department of Pathology, Vall d’Hebron University Hospital, Translational Molecular Pathology, Vall d’Hebron Institute of Research (VHIR), Universitat Autònoma de Barcelona and Spanish Biomedical Research Network Centre in Oncology (CIBERONC)
- Paolo Nuciforo
- Molecular Oncology Group, Vall d’Hebron Institute of Oncology (VHIO)
- Camille Stephan-Otto Attolini
- Bioinformatics-Biostatistics Unit, Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST)
- M. Mar Albà
- IMIM - Hospital del Mar Medical Research Institute
- Javier Muñoz
- Proteomics Unit, Spanish National Cancer Research Centre (CNIO)
- Tian V. Tian
- Noncolorectal Gastrointestinal Cancer Translational Research Group, Vall d’Hebron Institute of Oncology (VHIO)
- Ignacio Varela
- Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria - CSIC
- Ana Vivancos
- Cancer Genomics Group, Vall d’Hebron Institute of Oncology (VHIO)
- Santiago Ramón y Cajal
- Department of Pathology, Vall d’Hebron University Hospital, Translational Molecular Pathology, Vall d’Hebron Institute of Research (VHIR), Universitat Autònoma de Barcelona and Spanish Biomedical Research Network Centre in Oncology (CIBERONC)
- Purificación Muñoz
- Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL)
- Carmen Rivas
- Centro de Investigación en Medicina Molecular (CIMUS), Universidad de Santiago de Compostela and Instituto de Investigaciones Sanitarias (IDIS)
- María Abad
- Cellular Plasticity and Cancer Group, Vall d’Hebron Institute of Oncology (VHIO)
- DOI
- https://doi.org/10.1038/s41467-022-34529-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 22
Abstract
Small proteins encoded by previously assumed non-coding RNAs can have cell regulatory functions. Here the authors report that TINCR lncRNA encodes pTINCR, a ubiquitin-like protein (UBL) that promotes epithelial differentiation through the SUMOylation and activation of CDC42, and it has tumour suppressor activity in epithelial cancers.
