NEUROPROTECTIVE AND MNEMOTROPIC EFFECTS OF SOMNIFACIENTS AT DIFFUSE AXONAL INJURY

Abstract

Neuroprotective features of somnifacients were studied in animals with diffuse axonal injuries (DAI). It was established that in the presence of DAI Zopiclone had evident anticonvulsant and slight antihypoxic actions mainly in early period of trauma. Zolpidem had evident anti-ischemic action, slight antihypoxic and moderate anticonvulsant actions in late posttraumatic period. Zopiclone and Золпидем significantly restored short-term and long-term memory after diffuse axonal injuries.

Keywords

• diffuse axonal injury
• zopiclone
• zolpidem
• neuroprotection