Communications Biology (Apr 2021)
A collagen glucosyltransferase drives lung adenocarcinoma progression in mice
- Hou-Fu Guo,
- Neus Bota-Rabassedas,
- Masahiko Terajima,
- B. Leticia Rodriguez,
- Don L. Gibbons,
- Yulong Chen,
- Priyam Banerjee,
- Chi-Lin Tsai,
- Xiaochao Tan,
- Xin Liu,
- Jiang Yu,
- Michal Tokmina-Roszyk,
- Roma Stawikowska,
- Gregg B. Fields,
- Mitchell D. Miller,
- Xiaoyan Wang,
- Juhoon Lee,
- Kevin N. Dalby,
- Chad J. Creighton,
- George N. Phillips,
- John A. Tainer,
- Mitsuo Yamauchi,
- Jonathan M. Kurie
Affiliations
- Hou-Fu Guo
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Neus Bota-Rabassedas
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Masahiko Terajima
- Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill
- B. Leticia Rodriguez
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Don L. Gibbons
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Yulong Chen
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Priyam Banerjee
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Chi-Lin Tsai
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Xiaochao Tan
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Xin Liu
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jiang Yu
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Michal Tokmina-Roszyk
- Institute for Human Health & Disease Intervention (I-HEALTH) and Department of Chemistry & Biochemistry, Florida Atlantic University
- Roma Stawikowska
- Institute for Human Health & Disease Intervention (I-HEALTH) and Department of Chemistry & Biochemistry, Florida Atlantic University
- Gregg B. Fields
- Institute for Human Health & Disease Intervention (I-HEALTH) and Department of Chemistry & Biochemistry, Florida Atlantic University
- Mitchell D. Miller
- Department of Biosciences, Rice University
- Xiaoyan Wang
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Juhoon Lee
- Division of Medicinal Chemistry, Targeted Therapeutic Drug Discovery and Development Program, College of Pharmacy, The University of Texas at Austin
- Kevin N. Dalby
- Division of Medicinal Chemistry, Targeted Therapeutic Drug Discovery and Development Program, College of Pharmacy, The University of Texas at Austin
- Chad J. Creighton
- Department of Medicine, Dan L. Duncan Cancer Center, Baylor College of Medicine
- George N. Phillips
- Department of Biosciences, Rice University
- John A. Tainer
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Mitsuo Yamauchi
- Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill
- Jonathan M. Kurie
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s42003-021-01982-w
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 10
Abstract
Guo et al. determine the molecular basis of collagen lysyl hydroxylase 2 (LH2) substrate specificity. They further show that LH2 also functions as a collagen glucosyltransferase to promote lung cancer progression.
