Primary cilia-associated signalling in squamous cell carcinoma of head and neck region

Iveta Putnová; Iveta Putnová; Barbora Moldovan Putnová; Barbora Moldovan Putnová; Pavel Hurník; Pavel Hurník; Pavel Hurník; Jan Štembírek; Jan Štembírek; Marcela Buchtová; Marcela Buchtová; Petra Kolísková; Petra Kolísková

doi:10.3389/fonc.2024.1413255

Frontiers in Oncology (Aug 2024)

Primary cilia-associated signalling in squamous cell carcinoma of head and neck region

Iveta Putnová,
Iveta Putnová,
Barbora Moldovan Putnová,
Barbora Moldovan Putnová,
Pavel Hurník,
Pavel Hurník,
Pavel Hurník,
Jan Štembírek,
Jan Štembírek,
Marcela Buchtová,
Marcela Buchtová,
Petra Kolísková,
Petra Kolísková

Affiliations

Iveta Putnová: Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia
Iveta Putnová: Department of Anatomy, Histology and Embryology, University of Veterinary Sciences Brno, Brno, Czechia
Barbora Moldovan Putnová: Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia
Barbora Moldovan Putnová: Department of Pathological Morphology and Parasitology, University of Veterinary Sciences Brno, Brno, Czechia
Pavel Hurník: Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia
Pavel Hurník: Institute of Molecular and Clinical Pathology and Medical Genetics, University Hospital Ostrava, Ostrava, Czechia
Pavel Hurník: Institute of Molecular and Clinical Pathology and Medical Genetics, Faculty of Medicine, University of Ostrava, Ostrava, Czechia
Jan Štembírek: Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia
Jan Štembírek: Department of Maxillofacial Surgery, University Hospital Ostrava, Ostrava, Czechia
Marcela Buchtová: Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia
Marcela Buchtová: Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czechia
Petra Kolísková: Laboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czechia
Petra Kolísková: Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czechia

DOI: https://doi.org/10.3389/fonc.2024.1413255
Journal volume & issue: Vol. 14

Abstract

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Squamous cell carcinoma (SCC) of the head and neck originates from the mucosal lining of the upper aerodigestive tract, including the lip, tongue, nasopharynx, oropharynx, larynx and hypopharynx. In this review, we summarise what is currently known about the potential function of primary cilia in the pathogenesis of this disease. As primary cilia represent a key cellular structure for signal transduction and are related to cell proliferation, an understanding of their role in carcinogenesis is necessary for the design of new treatment approaches. Here, we introduce cilia-related signalling in head and neck squamous cell carcinoma (HNSCC) and its possible association with HNSCC tumorigenesis. From this point of view, PDGF, EGF, Wnt and Hh signalling are discussed as all these pathways were found to be dysregulated in HNSCC. Moreover, we review the clinical potential of small molecules affecting primary cilia signalling to target squamous cell carcinoma of the head and neck area.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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Abstract

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