Intrahost Monkeypox Virus Genome Variation in Patient with Early Infection, Finland, 2022

Abstract

Monkeypox virus was imported into Finland during late May–early June 2022. Intrahost viral genome variation in a sample from 1 patient comprised a major variant with 3 lineage B.1.3–specific mutations and a minor variant with ancestral B.1 nucleotides. Results suggest either ongoing APOBEC3 enzyme–mediated evolution or co-infection.

Keywords

• Monkeypox virus
• outbreak
• intrahost variation
• genomic sequence
• APOBEC3-associated mutations
• viruses