Journal of Pharmacy & Pharmaceutical Sciences (Apr 2020)
Prevention and therapy of COVID-19 via exogenous estrogen treatment for both male and female patients
Abstract
The presented work summarizes the results of studies underlining the crucial role of estrogen receptor (ER) signaling in both innate and adaptive immune responses as well as in tissue repairing processes during respiratory virus infection. Experimental studies justify that there are no quite different pathways for immune defenses against respiratory virus infection in males and females, but rather the physiologically weaker ER signaling results in an increased morbidity and mortality among men with pulmonary virus infection. In animal experiments, estrogen treatment silences the inflammatory reactions and decreases virus titers leading to improved survival rate; it seems to be an ideal prevention and therapy against COVID-19. We should overcome the widespread reluctance to estrogen therapy as we have a unique estrogen formula; Premarin deriving from natural sources. Premarin can exert similar ER upregulative and gene repairing power like endogenous estrogen without any risk for adverse reactions. Premarin is capable of stopping the COVID-19 pandemic.
