Nature Communications (Mar 2021)
Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment
- Min Zhang,
- Jin-Li Luo,
- Qianqian Sun,
- James Harber,
- Alan G. Dawson,
- Apostolos Nakas,
- Sara Busacca,
- Annabel J. Sharkey,
- David Waller,
- Michael T. Sheaff,
- Cathy Richards,
- Peter Wells-Jordan,
- Aarti Gaba,
- Charlotte Poile,
- Essa Y. Baitei,
- Aleksandra Bzura,
- Joanna Dzialo,
- Maymun Jama,
- John Le Quesne,
- Amrita Bajaj,
- Luke Martison,
- Jacqui A. Shaw,
- Catrin Pritchard,
- Tamihiro Kamata,
- Nathaniel Kuse,
- Lee Brannan,
- Pan De Philip Zhang,
- Hongji Yang,
- Gareth Griffiths,
- Gareth Wilson,
- Charles Swanton,
- Frank Dudbridge,
- Edward J. Hollox,
- Dean A. Fennell
Affiliations
- Min Zhang
- Novogene Co., Ltd, Building 301
- Jin-Li Luo
- Bioinformatics and Biostatistics Support Hub, University of Leicester
- Qianqian Sun
- Novogene Co., Ltd, Building 301
- James Harber
- Department of Genetics and Genome Biology, University of Leicester
- Alan G. Dawson
- Department of Genetics and Genome Biology, University of Leicester
- Apostolos Nakas
- Department of Cardiothoracic Surgery, Glenfield Hospital
- Sara Busacca
- Department of Genetics and Genome Biology, University of Leicester
- Annabel J. Sharkey
- University of Sheffield Teaching Hospitals
- David Waller
- Barts Health NHS Trust, The Royal London Hospital
- Michael T. Sheaff
- Barts Health NHS Trust, The Royal London Hospital
- Cathy Richards
- Department of Pathology, Leicester Royal Infirmary, Infirmary Square
- Peter Wells-Jordan
- Department of Pathology, Leicester Royal Infirmary, Infirmary Square
- Aarti Gaba
- Department of Genetics and Genome Biology, University of Leicester
- Charlotte Poile
- Department of Genetics and Genome Biology, University of Leicester
- Essa Y. Baitei
- Department of Genetics and Genome Biology, University of Leicester
- Aleksandra Bzura
- Department of Genetics and Genome Biology, University of Leicester
- Joanna Dzialo
- Department of Genetics and Genome Biology, University of Leicester
- Maymun Jama
- Department of Genetics and Genome Biology, University of Leicester
- John Le Quesne
- Institute of Cancer Sciences, University of Glasgow, Garscube Estate
- Amrita Bajaj
- Department of Radiology, Glenfield Hospital
- Luke Martison
- Department of Genetics and Genome Biology, University of Leicester
- Jacqui A. Shaw
- Department of Genetics and Genome Biology, University of Leicester
- Catrin Pritchard
- Department of Genetics and Genome Biology, University of Leicester
- Tamihiro Kamata
- Department of Genetics and Genome Biology, University of Leicester
- Nathaniel Kuse
- Department of Genetics and Genome Biology, University of Leicester
- Lee Brannan
- Department of Health Sciences, University of Leicester
- Pan De Philip Zhang
- Department of Informatics, University of Leicester
- Hongji Yang
- Department of Informatics, University of Leicester
- Gareth Griffiths
- Southampton Clinical Trials Unit, University of Southampton
- Gareth Wilson
- The Francis Crick Institute
- Charles Swanton
- The Francis Crick Institute
- Frank Dudbridge
- Department of Health Sciences, University of Leicester
- Edward J. Hollox
- Department of Genetics and Genome Biology, University of Leicester
- Dean A. Fennell
- Department of Genetics and Genome Biology, University of Leicester
- DOI
- https://doi.org/10.1038/s41467-021-21798-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
The impact of intratumour heterogeneity on immune surveillance and clinical outcomes has not been adequately explored in malignant pleural mesothelioma (MPM). Here the authors analyse the influence of evolution on the survival and immune landscape of MPM patients using multi-region sequencing data.
