Frontiers in Immunology (Aug 2024)

Plasma concentrations of IL-6, MIP-1β, IP-10, and PTX-3 as predictors of the immunological response to antiretroviral treatment in people with HIV

  • Marta Mejías-Trueba,
  • Marta Mejías-Trueba,
  • Abraham Saborido-Alconchel,
  • Ana Serna-Gallego,
  • María Trujillo-Rodríguez,
  • Esperanza Muñoz-Muela,
  • Silvia Llaves-Flores,
  • Nuria Espinosa,
  • Cristina Roca-Oporto,
  • Marta Herrero,
  • Cesar Sotomayor,
  • Luis F. López-Cortes

DOI
https://doi.org/10.3389/fimmu.2024.1447926
Journal volume & issue
Vol. 15

Abstract

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Despite effective antiretroviral therapy (ART), 15-30% of people with HIV experience poor CD4+ T-cell recovery, termed immunologic non-responders (INR). This study aims to evaluate whether pre-ART plasma levels of interleukin-6 (IL-6), interferon gamma-induced protein-10 (IP-10), macrophage inflammatory protein-1-β (MIP-1β), and/or pentraxin-3 (PTX-3) could predict subsequent immunologic recovery. Seventy-four participants were enrolled and classified as INR and immunologic responders (IR) based on CD4+/CD8+ ratio increase over 24 months after starting ART. The results showed no significant differences in cytokine levels between INR and IR. Therefore, IL-6, IP-10, MIP-1β, and PTX-3 were unsuitable as predictive markers of poor immune recovery.

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