A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche

Jlenia Guarnerio; Lourdes Maria Mendez; Noboru Asada; Archita Venugopal Menon; Jacqueline Fung; Kelsey Berry; Paul S. Frenette; Keisuke Ito; Pier Paolo Pandolfi

doi:10.1038/s41467-017-02427-x

Nature Communications (Jan 2018)

A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche

Jlenia Guarnerio,
Lourdes Maria Mendez,
Noboru Asada,
Archita Venugopal Menon,
Jacqueline Fung,
Kelsey Berry,
Paul S. Frenette,
Keisuke Ito,
Pier Paolo Pandolfi

Affiliations

Jlenia Guarnerio: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Lourdes Maria Mendez: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Noboru Asada: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Medicine and Cell Biology, Albert Einstein College of Medicine, Michael F. Price Center
Archita Venugopal Menon: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Jacqueline Fung: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Kelsey Berry: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Paul S. Frenette: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Medicine and Cell Biology, Albert Einstein College of Medicine, Michael F. Price Center
Keisuke Ito: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Department of Medicine and Cell Biology, Albert Einstein College of Medicine, Michael F. Price Center
Pier Paolo Pandolfi: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-017-02427-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

Read online

Persistence of resistant leukemic cells after therapy is the main cause of relapse. Here, the authors show that mesenchymal stem cells-derived PML is involved in the maintenance of leukemia cells through Cxcl1 and IL6 and that PML inhibition enhances sensitivity to chemotherapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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