Can Prohibitin 1 be a Safeguard against liver disease?

Lei Xia; Yuling Liu; Sujun Zhang; Yurong Yang; Zhigang Zhou; Jian Tu

Annals of Hepatology (Nov 2019)

Can Prohibitin 1 be a Safeguard against liver disease?

Lei Xia,
Yuling Liu,
Sujun Zhang,
Yurong Yang,
Zhigang Zhou,
Jian Tu

Affiliations

Lei Xia: Institute of Pharmacy and Pharmacology, University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, Hunan, China
Yuling Liu: Institute of Pharmacy and Pharmacology, University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, Hunan, China
Sujun Zhang: Medical Research Center, University of South China, Hengyang, Hunan, China
Yurong Yang: Institute of Pharmacy and Pharmacology, University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, Hunan, China
Zhigang Zhou: The First Affiliated Hospital, University of South China, Hengyang, Hunan, China; Corresponding authors:
Jian Tu: The First Affiliated Hospital, University of South China, Hengyang, Hunan, China; Institute of Pharmacy and Pharmacology, University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, Hunan, China; Corresponding authors:

Journal volume & issue: Vol. 18, no. 6
pp. 790 – 795

Abstract

Read online

Prohibitin (PHB) 1 is involved in multiple regulatory pathways in liver disease to protect hepatocytes, and its function is associated with subcellular localization. PHB1 located in the nucleus, cytoplasm and the mitochondrial inner membrane has anti-oxidative stress and anti-inflammatory effects in hepatitis and cirrhosis, which can protect liver cells from damage caused by inflammatory factors and reactive oxygen species (ROS) stimulation. The low expression of PHB1 located in the nucleus of liver cancer cells inhibits the proliferation and metastasis of liver cancer; thus, PHB1 exhibits the function of a tumor suppressor gene. Understanding the mechanisms of PHB1 in liver diseases may be useful for further research on the disease and may provide new ideas for the development of targeted therapeutic drugs in the future. Therefore, this review puts forward an overview of the role of PHB1 and its protective mechanism in liver diseases.

Published in Annals of Hepatology

ISSN: 1665-2681 (Print); 2659-5982 (Online)
Publisher: Elsevier
Country of publisher: Spain
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine
Website: https://www.journals.elsevier.com/annals-of-hepatology

About the journal

Abstract

Keywords