Characterization of the Sideritis scardica Extract SidTea+TM and Its Effect on Physiological Profile, Metabolic Health and Redox Biomarkers in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study

Konstantinos Papanikolaou; Konstantinos Kouloridas; Anastasia Rosvoglou; Athanasios Gatsas; Kalliopi Georgakouli; Chariklia K. Deli; Dimitrios Draganidis; Aikaterini Argyropoulou; Dimitris Michailidis; Ioannis G. Fatouros; Athanasios Z. Jamurtas

doi:10.3390/molecules29051113

Molecules (Mar 2024)

Characterization of the Sideritis scardica Extract SidTea+TM and Its Effect on Physiological Profile, Metabolic Health and Redox Biomarkers in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study

Konstantinos Papanikolaou,
Konstantinos Kouloridas,
Anastasia Rosvoglou,
Athanasios Gatsas,
Kalliopi Georgakouli,
Chariklia K. Deli,
Dimitrios Draganidis,
Aikaterini Argyropoulou,
Dimitris Michailidis,
Ioannis G. Fatouros,
Athanasios Z. Jamurtas

Affiliations

Konstantinos Papanikolaou: Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece
Konstantinos Kouloridas: Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece
Anastasia Rosvoglou: Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece
Athanasios Gatsas: Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece
Kalliopi Georgakouli: Department of Nutrition and Dietetics, University of Thessaly, 42132 Trikala, Greece
Chariklia K. Deli: Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece
Dimitrios Draganidis: Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece
Aikaterini Argyropoulou: Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece
Dimitris Michailidis: Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece
Ioannis G. Fatouros: Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece
Athanasios Z. Jamurtas: Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece

DOI: https://doi.org/10.3390/molecules29051113
Journal volume & issue: Vol. 29, no. 5
p. 1113

Abstract

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This study aimed to characterize a Sideritis scardica extract (SidTea+TM) and investigate its effect on the physiological profile, metabolic health and redox status in healthy individuals. The chemical profile and antioxidant potential of the SidTea+TM extract were evaluated by UPLC-HRMS analysis and in vitro cell-free methods. Twenty-eight healthy adults participated in this randomized, double-blind, placebo-controlled study. Participants consumed 1500 mg/day of SidTea+TM or a placebo for 4 weeks. At baseline and post-supplementation, participants were assessed for their anthropometric and physiological profile and provided a resting blood sample. SidTea+TM decreased (p p TM also resulted in an increase (p 2max (+1.1 mL/kg/min) and a reduction (p TM increased (p p TM is a potent and safe to use antioxidant that can elicit positive changes in indices of blood pressure, cardiorespiratory capacity, liver metabolism, and redox status in healthy adults over a 4-week supplementation period.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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