Autotransplantation of T-lymphocytes as a tool for antigen-specific immunotherapy of oncological diseases

Abstract

Autotransplantation of immune cells to induce immunological rejection of tumors can be a useful approach in tumor treatment. Despite the low efficiency of this approach demonstrated in the past, the active development of cell technologies and genetic engineering has led to the significant improvement in clinical outcomes. A great success was achieved in adoptive immunotherapy with the T-lymphocytes specific to tumor antigens. This review describes the clinical experience in application of various antigen-specific adoptive immunotherapy methods including tumor-infiltrating T-lymphocytes, T-lymphocytes with redirected transgenic T-cell and chimeric antigenrecognizing receptors. The possibilities and limitations of these biomedical technologies are also analyzed in the article.

Keywords

• т-lymphocytes
• cellular transplantation
• adoptive immunotherapy
• malignant tumors
• tumorinfiltrating lymphocytes
• transgenic antigen-recognition receptor
• chimeric antigen-recognition receptor