The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families

Yichen Zhong; Hakimeh Moghaddas Sani; Bishnu P. Paudel; Jason K. K. Low; Ana P. G. Silva; Stefan Mueller; Chandrika Deshpande; Santosh Panjikar; Xavier J. Reid; Max J. Bedward; Antoine M. van Oijen; Joel P. Mackay

doi:10.1038/s41467-022-35002-0

Nature Communications (Dec 2022)

The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families

Yichen Zhong,
Hakimeh Moghaddas Sani,
Bishnu P. Paudel,
Jason K. K. Low,
Ana P. G. Silva,
Stefan Mueller,
Chandrika Deshpande,
Santosh Panjikar,
Xavier J. Reid,
Max J. Bedward,
Antoine M. van Oijen,
Joel P. Mackay

Affiliations

Yichen Zhong: School of Life and Environmental Sciences, University of Sydney
Hakimeh Moghaddas Sani: School of Life and Environmental Sciences, University of Sydney
Bishnu P. Paudel: Molecular Horizons, School of Chemistry and Molecular Bioscience, University of Wollongong
Jason K. K. Low: School of Life and Environmental Sciences, University of Sydney
Ana P. G. Silva: School of Life and Environmental Sciences, University of Sydney
Stefan Mueller: Molecular Horizons, School of Chemistry and Molecular Bioscience, University of Wollongong
Chandrika Deshpande: School of Life and Environmental Sciences, University of Sydney
Santosh Panjikar: Australian Synchrotron
Xavier J. Reid: School of Life and Environmental Sciences, University of Sydney
Max J. Bedward: School of Life and Environmental Sciences, University of Sydney
Antoine M. van Oijen: Molecular Horizons, School of Chemistry and Molecular Bioscience, University of Wollongong
Joel P. Mackay: School of Life and Environmental Sciences, University of Sydney

DOI: https://doi.org/10.1038/s41467-022-35002-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

Read online

CHD4 is an essential chromatin remodelling enzyme in complex organisms. Here the authors demonstrate that CHD4 activity is regulated both positively and negatively by distinct auxiliary domains, revealing parallels with other chromatin remodellers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal