BMC Research Notes (Jan 2012)

Evaluation of prognostic factors and the role of chemotherapy in unfavorable carcinoma of unknown primary site: a 10-year cohort study

  • Chen Kuo-Wei,
  • Liu Chia-Jen,
  • Lu Hsueh-Ju,
  • Tzeng Cheng-Hwai,
  • Liu Jin-Hwang,
  • Chiou Tzeon-Jye,
  • Yen Chueh-Chuan,
  • Wang Wei-Shu,
  • Chao Ta-Chung,
  • Teng Hao-Wei,
  • Chen Ming-Huang,
  • Liu Chun-Yu,
  • Chang Peter MH,
  • Yang Muh-Hwa

DOI
https://doi.org/10.1186/1756-0500-5-70
Journal volume & issue
Vol. 5, no. 1
p. 70

Abstract

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Abstract Background Carcinoma of unknown primary site (CUP) has a poor prognosis and the prognostic factors in these patients are not well established. Furthermore, there are no selection criteria for patients who should benefit from chemotherapy. Methods The medical records of 179 CUP patients who were treated at Taipei Veterans General Hospital from 2000 to 2009 were reviewed. Factors associated with survival were determined by Kaplan-Meier analysis. Differences between the groups with and without palliative chemotherapy were analyzed. Results Univariate analysis revealed multiple prognostic factors, including performance status, lung metastasis, number of metastatic organs, serum albumin, corrected serum calcium, lactate dehydrogenase (LDH), sodium, and cholesterol levels, palliative chemotherapy, and white blood cell and lymphocyte counts. Multivariate analysis showed that performance status Conclusions Certain patients with unfavorable CUP will have better survival. Identification of patients with unfavorable CUP who could benefit from palliative chemotherapy warrants future prospective studies.