Nature Communications (Jul 2018)
Genomic analysis of a pre-elimination Malaysian Plasmodium vivax population reveals selective pressures and changing transmission dynamics
- Sarah Auburn,
- Ernest D. Benavente,
- Olivo Miotto,
- Richard D. Pearson,
- Roberto Amato,
- Matthew J. Grigg,
- Bridget E. Barber,
- Timothy William,
- Irene Handayuni,
- Jutta Marfurt,
- Hidayat Trimarsanto,
- Rintis Noviyanti,
- Kanlaya Sriprawat,
- Francois Nosten,
- Susana Campino,
- Taane G. Clark,
- Nicholas M. Anstey,
- Dominic P. Kwiatkowski,
- Ric N. Price
Affiliations
- Sarah Auburn
- Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University
- Ernest D. Benavente
- Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine
- Olivo Miotto
- Big Data Institute, Li Ka Shing Centre for Health Information and Discovery
- Richard D. Pearson
- Big Data Institute, Li Ka Shing Centre for Health Information and Discovery
- Roberto Amato
- Big Data Institute, Li Ka Shing Centre for Health Information and Discovery
- Matthew J. Grigg
- Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University
- Bridget E. Barber
- Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University
- Timothy William
- Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit
- Irene Handayuni
- Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University
- Jutta Marfurt
- Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University
- Hidayat Trimarsanto
- Eijkman Institute for Molecular Biology
- Rintis Noviyanti
- Eijkman Institute for Molecular Biology
- Kanlaya Sriprawat
- Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Francois Nosten
- Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Susana Campino
- Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine
- Taane G. Clark
- Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine
- Nicholas M. Anstey
- Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University
- Dominic P. Kwiatkowski
- Big Data Institute, Li Ka Shing Centre for Health Information and Discovery
- Ric N. Price
- Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University
- DOI
- https://doi.org/10.1038/s41467-018-04965-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Plasmodium vivax incidence in Malaysia has declined markedly over the last decade, despite evidence of chloroquine resistance. Here, Auburn et al. compare population structure of P. vivax in Malaysia to regions with intermediate and high transmission and identify genetic regions under putative selection.
