Nature Communications (Apr 2020)
GPR56/ADGRG1 is associated with response to antidepressant treatment
- Raoul Belzeaux,
- Victor Gorgievski,
- Laura M. Fiori,
- Juan Pablo Lopez,
- Julien Grenier,
- Rixing Lin,
- Corina Nagy,
- El Chérif Ibrahim,
- Eduardo Gascon,
- Philippe Courtet,
- Stéphane Richard-Devantoy,
- Marcelo Berlim,
- Eduardo Chachamovich,
- Jean-François Théroux,
- Sylvie Dumas,
- Bruno Giros,
- Susan Rotzinger,
- Claudio N. Soares,
- Jane A. Foster,
- Naguib Mechawar,
- Gregory G. Tall,
- Eleni T. Tzavara,
- Sidney H. Kennedy,
- Gustavo Turecki
Affiliations
- Raoul Belzeaux
- Douglas Mental Health University Institute, Department of Psychiatry, McGill University
- Victor Gorgievski
- CNRS (Integrative Neuroscience and Cognition Center, UMR 8002)
- Laura M. Fiori
- Douglas Mental Health University Institute, Department of Psychiatry, McGill University
- Juan Pablo Lopez
- Douglas Mental Health University Institute, Department of Psychiatry, McGill University
- Julien Grenier
- INSERM UMR-S 1124 ERL 3649, Université Paris Descartes
- Rixing Lin
- Douglas Mental Health University Institute, Department of Psychiatry, McGill University
- Corina Nagy
- Douglas Mental Health University Institute, Department of Psychiatry, McGill University
- El Chérif Ibrahim
- Aix-Marseille Univ, AP-HM, CNRS, INT, Inst Neurosci Timone, Hôpital Sainte Marguerite, Pôle de psychiatrie
- Eduardo Gascon
- Aix-Marseille Univ, AP-HM, CNRS, INT, Inst Neurosci Timone, Hôpital Sainte Marguerite, Pôle de psychiatrie
- Philippe Courtet
- Fondation FondaMental
- Stéphane Richard-Devantoy
- Douglas Mental Health University Institute, Department of Psychiatry, McGill University
- Marcelo Berlim
- Douglas Mental Health University Institute, Department of Psychiatry, McGill University
- Eduardo Chachamovich
- Douglas Mental Health University Institute, Department of Psychiatry, McGill University
- Jean-François Théroux
- Douglas Mental Health University Institute, Department of Psychiatry, McGill University
- Sylvie Dumas
- Oramacell
- Bruno Giros
- Douglas Mental Health University Institute, Department of Psychiatry, McGill University
- Susan Rotzinger
- Centre for Mental Health, Department of Psychiatry, University Health Network, Krembil Research Institute, University of Toronto
- Claudio N. Soares
- St Michael’s Hospital, Li Ka Shing Knowledge Institute, Centre for Depression and Suicide Studies
- Jane A. Foster
- Centre for Mental Health, Department of Psychiatry, University Health Network, Krembil Research Institute, University of Toronto
- Naguib Mechawar
- Douglas Mental Health University Institute, Department of Psychiatry, McGill University
- Gregory G. Tall
- Department of Pharmacology, University of Michigan
- Eleni T. Tzavara
- Fondation FondaMental
- Sidney H. Kennedy
- Centre for Mental Health, Department of Psychiatry, University Health Network, Krembil Research Institute, University of Toronto
- Gustavo Turecki
- Douglas Mental Health University Institute, Department of Psychiatry, McGill University
- DOI
- https://doi.org/10.1038/s41467-020-15423-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
It is not fully understood why some patients respond or do not respond to antidepressant treatment. Here the authors show that in the blood of individuals with depression, GPR56 expression increases in responders to antidepressant treatment, but not in non-responders.
