BMC Cancer (May 2022)

Prognostic value of CD4+ T lymphopenia in non-small cell lung Cancer

  • Guillaume Eberst,
  • Dewi Vernerey,
  • Caroline Laheurte,
  • Aurélia Meurisse,
  • Vincent Kaulek,
  • Laurie Cuche,
  • Pascale Jacoulet,
  • Hamadi Almotlak,
  • Jean Lahourcade,
  • Marie Gainet-Brun,
  • Elizabeth Fabre,
  • Françoise Le Pimpec-Barthes,
  • Olivier Adotevi,
  • Virginie Westeel

DOI
https://doi.org/10.1186/s12885-022-09628-8
Journal volume & issue
Vol. 22, no. 1
pp. 1 – 11

Abstract

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Highlights This study investigates the unknown prognostic influence of peripheral blood CD4+ T lymphopenia in non-small cell lung cancer (NSCLC) with long-term follow-up CD4+ but not CD8 + T lymphopenia was associated with poor survival in patients with localized NSCLC The CD4+ T lymphopenia appears to be an independent prognostic factor for poor overall survival in local/loco-regional NSCLC. CD4+ T lymphocyte count ≤500/μL in peripheral blood is associated with a high risk of death in NSCLC

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