Cis-(3-benzyloxy-1,1-cyclobutanedicarboxylato κ²O,O′)bis(1-methyl-1<i>H</i>-pyrazole)platinum(II)

Abstract

A huge variety of types of cancer makes it necessary to search for new effective drugs with a defined molecular target. Modification of substituents in ligands based on 3-hydroxy-1,1-cyclobutanedicarboxylic acid are one of the effective directions to design a better version of carboplatin. In the present study, we combined in one molecule a derivative of 3-hydroxycyclobutane-1,1-dicarboxylic acid and N-methylpyrazole as a carrier ligand. The antiproliferative of the novel complex Pt(II) was established for cell lines HCT116, MCF7, A549, and WI38 by means of a standard MTT colorimetric assay.

Keywords

• platinum (II) complexes
• 1-methyl-1<i>H</i>-pyrazole ligand
• 3-(benzyloxy)cyclobutane-1,1-dicarboxylic acid
• antiproliferative activity