Frontiers in Aging Neuroscience (Jul 2022)

Abnormalities in the Fractional Amplitude of Low-Frequency Fluctuation and Functional Connectivity in Parkinson's Disease With Excessive Daytime Sleepiness

  • Yuheng Zi,
  • Yuheng Zi,
  • Sainan Cai,
  • Changlian Tan,
  • Tianyu Wang,
  • Qin Shen,
  • Qinru Liu,
  • Min Wang,
  • Junli Li,
  • Lin Zhang,
  • Fan Zhou,
  • Chendie Song,
  • Jiaying Yuan,
  • Yujing Liu,
  • Jun Liu,
  • Jun Liu,
  • Haiyan Liao,
  • Haiyan Liao

DOI
https://doi.org/10.3389/fnagi.2022.826175
Journal volume & issue
Vol. 14

Abstract

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BackgroundExcessive daytime sleepiness (EDS) is one of the most important non-motor symptoms of Parkinson's disease (PD), and its neuropathologic basis is still unclear.ObjectiveThis study investigated the changes of neuronal activity in PD patients with EDS (PD-EDS) in the resting state.MethodsForty-three PD patients were recruited and divided into the PD-EDS group (n = 21) and PD-NEDS group (PD patients without excessive daytime sleepiness, n = 22) according to the Epworth sleepiness scale (ESS) scores. Patients in both groups received resting-state functional magnetic resonance imaging (rs-fMRI). The differences in fractional amplitude of low-frequency fluctuation (fALFF) between the two groups, correlations between fALFF and ESS, and functional connection (FC) between the brain regions with different fALFF values and the whole brain were analyzed.ResultsPD-EDS patients exhibited a decreased fALFF in the Cingulum-Ant-R, but an increased fALFF in the Putamen-R and Thalamus-L when compared with PD-NEDS patients; an increased functional connectivity between these three seed regions with different fALFF values and the right medial frontal gyrus, bilateral superior temporal gyrus, left insular, and right precuneus was observed (p < 0.05), but a deceased functional connectivity between these three seed regions and the right cerebellum anterior lobe/right brainstem, right middle temporal gyrus and inferior temporal gyrus, right hippocampus/parahippocampal gyrus, right medial cingulate gyrus and bilateral middle occipital gyrus was observed (p < 0.05). The value of fALFF was negatively correlated with the ESS score in the Cingulum-Ant-R, but positively correlated with the ESS score in the Putamen-R and Thalamus-L.ConclusionsEDS in PD patients may be associated with changes in brain neuron activity and functional connectivity.

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