Nature Communications (Mar 2023)

Crocodile defensin (CpoBD13) antifungal activity via pH-dependent phospholipid targeting and membrane disruption

  • Scott A. Williams,
  • Fung T. Lay,
  • Guneet K. Bindra,
  • Suresh Banjara,
  • Ivan K. H. Poon,
  • Thanh Kha Phan,
  • Marc Kvansakul,
  • Mark D. Hulett

DOI
https://doi.org/10.1038/s41467-023-36280-y
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 11

Abstract

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Defensins are a class of host defence peptides that contribute to the immune system of eukaryotes. Here, the authors report the structure of saltwater crocodile defensin CpoBD13 and the mechanism of pH-dependent antifungal activity.