Journal of Nanobiotechnology (Jan 2008)

<it>N</it>-hexanoyl chitosan stabilized magnetic nanoparticles: Implication for cellular labeling and magnetic resonance imaging

  • Khil Myung S,
  • Sharma Manju,
  • Kim Sun Y,
  • Kc Remant B,
  • Bhattarai Shanta R,
  • Hwang Pyoung H,
  • Chung Gyung H,
  • Kim Hak Y

DOI
https://doi.org/10.1186/1477-3155-6-1
Journal volume & issue
Vol. 6, no. 1
p. 1

Abstract

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Abstract This project involved the synthesis of N-hexanoyl chitosan or simply modified chitosan (MC) stabilized iron oxide nanoparticles (MC-IOPs) and the biological evaluation of MC-IOPs. IOPs containing MC were prepared using conventional methods, and the extent of cell uptake was evaluated using mouse macrophages cell line (RAW cells). MC-IOPs were found to rapidly associate with the RAW cells, and saturation was typically reached within the 24 h of incubation at 37°C. Nearly 8.53 ± 0.31 pg iron/cell were bound or internalized at saturation. From these results, we conclude that MC-IOPs effectively deliver into RAW cells in vitro and we also hope MC-IOPs can be used for MRI enhancing agents in biomedical fields.