Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery

Vidya Mangala Prasad; Jelle S. Blijleven; Jolanda M. Smit; Kelly K. Lee

doi:10.1038/s41467-022-32431-9

Nature Communications (Aug 2022)

Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery

Vidya Mangala Prasad,
Jelle S. Blijleven,
Jolanda M. Smit,
Kelly K. Lee

Affiliations

Vidya Mangala Prasad: Department of Medicinal Chemistry, University of Washington
Jelle S. Blijleven: Zernike Institute for Advanced Materials, University of Groningen
Jolanda M. Smit: Department of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen
Kelly K. Lee: Department of Medicinal Chemistry, University of Washington

DOI: https://doi.org/10.1038/s41467-022-32431-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Membrane fusion is essential for cellular entry of enveloped viruses. Here, authors use time-resolved cryo-electron tomography and subtomogram averaging to capture 3D organization and population evolution of intermediates during membrane fusion of CHIKV, a medically important alphavirus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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