Xin yixue (Oct 2023)

Effect of ApoB/ApoA1 ratio on the all-cause mortality of patients with pulmonary embolism

  • Ouyang Xiaoli, Zhao Huijun, Chen Juping

DOI
https://doi.org/10.3969/j.issn.0253-9802.2023.10.013
Journal volume & issue
Vol. 54, no. 10
pp. 754 – 759

Abstract

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Objective To investigate the effect of ApoB/ApoA1 ratio on the all-cause mortality of patients with pulmonary embolism at admission. Methods One hundred and seventy-seven patients with hemodynamically stable pulmonary embolism were retrospectively collected. The time of admission was the start of follow up， June 30， 2022 was the end of follow up， and all-cause death was the outcome. The best cut-off value of ApoB/ApoA1 to predict all-cause death was calculated according to the receiver operating characteristic （ROC） curve. All patients were assigned into high ratio group （ApoB/ApoA1 ≥0.8） and low ratio group （ApoB/ApoA1 <0.8）. The effect of ApoB/ApoA1 ratio on the prognosis of pulmonary embolism patients was analyzed by univariate and multifactorial Cox regression models， and Kaplan-Meier analysis and Log-rank test was used to compare the survival. Results During the follow-up period， 43 patients died with a mortality of 24.3%. The best cut-off of ApoB/ApoA1 was 0.8 according to ROC and the area under the curve （AUC） was 0.805 （95% CI=0.738-0.872）. There were 39 deaths and 4 deaths in high ratio group and low ratio group， respectively， with a mortality of 52.0% and 3.9%， respectively. Univariate Cox proportional hazards regression model analysis showed that age， hazards stratification， D-Dimer， MPV/D-Dimer， blood urea nitrogen （BUN） and ApoB/ApoA1 were significant for the prognosis of pulmonary embolism patients （P < 0.05）. Multivariate Cox proportional hazards regression model analysis showed that age （P = 0.005）， ApoB/ApoA1 ratio （P < 0.001） and BUN （P < 0.001） were independent factors of the prognosis of pulmonary embolism patients. Log-rank test indicated that survival rate in high ratio group was significantly lower than that in low ratio group （χ2=58.166， P <0.001）. Conclusion A higher ApoB/ApoA1 ratio at admission is related to the higher risk of death in pulmonary embolism patients， and is an effective factor to predict all-cause mortality in pulmonary embolism patients.

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