Heating-induced decarboxylative cyclization for the synthesis of 5-trifluoromethyl-1,2,4-triazoles from trifluoroacetimidohydrazides and α-oxocarboxylic acids

Abstract

A simple metal and additive-free approach for the assembly of 5-trifluoromethyl-1,2,4-triazoles via only heating-induced decarboxylative cyclization of readily available trifluoroacetimidohydrazides and α-oxocarboxylic acids has been developed. In this protocol, the rarely reported tetrahedral carboxylic acids intermediate could be in-situ generated and undergo subsequent decarboxylation to afford the target heterocycle products.

Keywords

• Heating-induced
• Decarboxylative cyclization
• 5-Trifluoromethyl-1,2,4-triazoles
• Trifluoroacetimidohydrazides
• α-Oxocarboxylic acids
• Trifluoromethyl-substituted N-heterocycles