Primary hyperaldosteronism. Mechanisms and consequences of pathological influence on an organism (review of literature)

Abstract

The work is based on the analysis of world literature data on primary hyperaldosteronism. The data on mechanisms of pathological influences of excessive autonomous aldosterone secretion on the body systems are given. The ways of excessive aldosterone influence on the cardiovascular and nervous system, kidneys, quality and life expectancy are revealed. It is shown that aldosterone activates specific intracellular genomic and non-genomic pathways of influence on the cardiovascular system and induces the development of cardiofibrosis, atrial fibrillation and heart failure. Attention is drawn to the fact that hyperaldostero­nism is a cause of the development of metabolic syndrome, deterioration in quality of life and reduction of life expectancy.

Keywords

• primary hyperaldosteronism
• pathological consequences for an organism
• mechanisms of development
• review