Terpenoids from Cameroonian Oxystigma mannii (Baill.) Harms

J.H. Peyeino; G.B. Tabekoueng; H.L.M. Djomkam; M.K. Langat; N. Sadgrove; T. Prescott; H. Siddique; E. Mas-Claret; M.S. Isyaka; J.D. Wansi; J.C. Vardamides; A.F.K. Waffo

Scientific African (Jul 2021)

Terpenoids from Cameroonian Oxystigma mannii (Baill.) Harms

J.H. Peyeino,
G.B. Tabekoueng,
H.L.M. Djomkam,
M.K. Langat,
N. Sadgrove,
T. Prescott,
H. Siddique,
E. Mas-Claret,
M.S. Isyaka,
J.D. Wansi,
J.C. Vardamides,
A.F.K. Waffo

Affiliations

J.H. Peyeino: Department of Chemistry, Faculty of Science, University of Douala, Douala 24157, Cameroon
G.B. Tabekoueng: Department of Chemistry, Faculty of Science, University of Douala, Douala 24157, Cameroon
H.L.M. Djomkam: Department of Chemistry, Faculty of Science, University of Douala, Douala 24157, Cameroon
M.K. Langat: Jodrell Laboratory, Natural Capital and Plant Health Department, Royal Botanic Gardens Kew, Richmond, Surrey TW9 3DS, UK; Corresponding author.
N. Sadgrove: Jodrell Laboratory, Natural Capital and Plant Health Department, Royal Botanic Gardens Kew, Richmond, Surrey TW9 3DS, UK
T. Prescott: Jodrell Laboratory, Natural Capital and Plant Health Department, Royal Botanic Gardens Kew, Richmond, Surrey TW9 3DS, UK
H. Siddique: Jodrell Laboratory, Natural Capital and Plant Health Department, Royal Botanic Gardens Kew, Richmond, Surrey TW9 3DS, UK
E. Mas-Claret: Department of Chemistry, University of Surrey, Guildford GU2 7XH, UK
M.S. Isyaka: Department of Chemistry, University of Surrey, Guildford GU2 7XH, UK
J.D. Wansi: Department of Chemistry, Faculty of Science, University of Douala, Douala 24157, Cameroon
J.C. Vardamides: Department of Chemistry, Faculty of Science, University of Douala, Douala 24157, Cameroon
A.F.K. Waffo: Department of Chemistry, Faculty of Science, University of Douala, Douala 24157, Cameroon

Journal volume & issue: Vol. 12
p. e00751

Abstract

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We describe two new terpenoids, 3″,5″-dihydroxycinnamoyl-3β,28,30-dihydroxylup-20(29)-ene (1) and 6S,9S-dihydroxycasbe-3E,7E,11E-trien-5,10‑dione (2) and ten known asperglaucide, aridanin, isoscopoletin, maslinic acid, ursolic acid, oleanolic acid, lupeol, sitosterol, stigmasterol and stigmasterol-glucoside from a West African, GuineoCongolian mangrove and strand forest tree, Oxystigma mannii (Baill.) Harms. The structures of the new compounds were determined based on their 1D and 2D NMR, HRMS and FTIR. DP4+ probabilities were used to assign the configurations for compound 2. The two compounds were tested for their antimicrobial effects against Saccharomyces cerevisiae (BY4743), Escherichia coli (BW25113) and Bacillus subtilis (BY4743), but no inhibition was observed at the maximum concentrations tested (800 µM).

Published in Scientific African

ISSN: 2468-2276 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science
Website: https://www.journals.elsevier.com/scientific-african

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