Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory

Samuel M. Cohen; Benjamin Suutari; Xingzhi He; Yang Wang; Sandrine Sanchez; Natasha N. Tirko; Nataniel J. Mandelberg; Caitlin Mullins; Guangjun Zhou; Shuqi Wang; Ilona Kats; Alejandro Salah; Richard W. Tsien; Huan Ma

doi:10.1038/s41467-018-04705-8

Nature Communications (Jun 2018)

Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory

Samuel M. Cohen,
Benjamin Suutari,
Xingzhi He,
Yang Wang,
Sandrine Sanchez,
Natasha N. Tirko,
Nataniel J. Mandelberg,
Caitlin Mullins,
Guangjun Zhou,
Shuqi Wang,
Ilona Kats,
Alejandro Salah,
Richard W. Tsien,
Huan Ma

Affiliations

Samuel M. Cohen: Institute of Neuroscience, and Department of Neurology of Second Affiliated Hospital, Mental Health Center, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Benjamin Suutari: NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center
Xingzhi He: Institute of Neuroscience, and Department of Neurology of Second Affiliated Hospital, Mental Health Center, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Yang Wang: Institute of Neuroscience, and Department of Neurology of Second Affiliated Hospital, Mental Health Center, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Sandrine Sanchez: NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center
Natasha N. Tirko: NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center
Nataniel J. Mandelberg: NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center
Caitlin Mullins: NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center
Guangjun Zhou: Institute of Neuroscience, and Department of Neurology of Second Affiliated Hospital, Mental Health Center, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Shuqi Wang: Institute of Neuroscience, and Department of Neurology of Second Affiliated Hospital, Mental Health Center, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine
Ilona Kats: NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center
Alejandro Salah: NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center
Richard W. Tsien: NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center
Huan Ma: Institute of Neuroscience, and Department of Neurology of Second Affiliated Hospital, Mental Health Center, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine

DOI: https://doi.org/10.1038/s41467-018-04705-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Activity-dependent gene expression is thought to involve translocation of Ca2+/calmodulin (CaM) to the nucleus. Here, the authors examine a translocation-deficient mutant of γCaMKII, a Ca2+/CaM shuttle protein, to show that translocation of Ca2+/CaM is required for memory and synaptic plasticity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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