Nature Communications (Dec 2021)
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus
- Adrienne Tin,
- Pascal Schlosser,
- Pamela R. Matias-Garcia,
- Chris H. L. Thio,
- Roby Joehanes,
- Hongbo Liu,
- Zhi Yu,
- Antoine Weihs,
- Anselm Hoppmann,
- Franziska Grundner-Culemann,
- Josine L. Min,
- Victoria L. Halperin Kuhns,
- Adebowale A. Adeyemo,
- Charles Agyemang,
- Johan Ärnlöv,
- Nasir A. Aziz,
- Andrea Baccarelli,
- Murielle Bochud,
- Hermann Brenner,
- Jan Bressler,
- Monique M. B. Breteler,
- Cristian Carmeli,
- Layal Chaker,
- Josef Coresh,
- Tanguy Corre,
- Adolfo Correa,
- Simon R. Cox,
- Graciela E. Delgado,
- Kai-Uwe Eckardt,
- Arif B. Ekici,
- Karlhans Endlich,
- James S. Floyd,
- Eliza Fraszczyk,
- Xu Gao,
- Xīn Gào,
- Allan C. Gelber,
- Mohsen Ghanbari,
- Sahar Ghasemi,
- Christian Gieger,
- Philip Greenland,
- Megan L. Grove,
- Sarah E. Harris,
- Gibran Hemani,
- Peter Henneman,
- Christian Herder,
- Steve Horvath,
- Lifang Hou,
- Mikko A. Hurme,
- Shih-Jen Hwang,
- Sharon L. R. Kardia,
- Silva Kasela,
- Marcus E. Kleber,
- Wolfgang Koenig,
- Jaspal S. Kooner,
- Florian Kronenberg,
- Brigitte Kühnel,
- Christine Ladd-Acosta,
- Terho Lehtimäki,
- Lars Lind,
- Dan Liu,
- Donald M. Lloyd-Jones,
- Stefan Lorkowski,
- Ake T. Lu,
- Riccardo E. Marioni,
- Winfried März,
- Daniel L. McCartney,
- Karlijn A. C. Meeks,
- Lili Milani,
- Pashupati P. Mishra,
- Matthias Nauck,
- Christoph Nowak,
- Annette Peters,
- Holger Prokisch,
- Bruce M. Psaty,
- Olli T. Raitakari,
- Scott M. Ratliff,
- Alex P. Reiner,
- Ben Schöttker,
- Joel Schwartz,
- Sanaz Sedaghat,
- Jennifer A. Smith,
- Nona Sotoodehnia,
- Hannah R. Stocker,
- Silvia Stringhini,
- Johan Sundström,
- Brenton R. Swenson,
- Joyce B. J. van Meurs,
- Jana V. van Vliet-Ostaptchouk,
- Andrea Venema,
- Uwe Völker,
- Juliane Winkelmann,
- Bruce H. R. Wolffenbuttel,
- Wei Zhao,
- Yinan Zheng,
- The Estonian Biobank Research Team,
- The Genetics of DNA Methylation Consortium,
- Marie Loh,
- Harold Snieder,
- Melanie Waldenberger,
- Daniel Levy,
- Shreeram Akilesh,
- Owen M. Woodward,
- Katalin Susztak,
- Alexander Teumer,
- Anna Köttgen
Affiliations
- Adrienne Tin
- Department of Medicine, University of Mississippi Medical Center
- Pascal Schlosser
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Pamela R. Matias-Garcia
- Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Chris H. L. Thio
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Roby Joehanes
- Framingham Heart Study
- Hongbo Liu
- Department of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine
- Zhi Yu
- Program in Medical and Population Genetics, Broad Institute
- Antoine Weihs
- Department of Psychiatry and Psychotherapy, University Medicine Greifswald
- Anselm Hoppmann
- Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg
- Franziska Grundner-Culemann
- Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg
- Josine L. Min
- MRC Integrative Epidemiology Unit, University of Bristol
- Victoria L. Halperin Kuhns
- Department of Physiology, University of Maryland School of Medicine
- Adebowale A. Adeyemo
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Charles Agyemang
- Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, University of Amsterdam
- Johan Ärnlöv
- Department of Neurobiology, Care Sciences and Society (NVS), Family Medicine and Primary Care Unit, Karolinska Institutet
- Nasir A. Aziz
- Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE)
- Andrea Baccarelli
- Laboratory of Environmental Precision Health, Mailman School of Public Health, Columbia University
- Murielle Bochud
- Center for Primary Care and Public Health (Unisanté), University of Lausanne
- Hermann Brenner
- German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research
- Jan Bressler
- Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Monique M. B. Breteler
- Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE)
- Cristian Carmeli
- Center for Primary Care and Public Health (Unisanté), University of Lausanne
- Layal Chaker
- Department of Epidemiology, Erasmus University Medical Center
- Josef Coresh
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Tanguy Corre
- Center for Primary Care and Public Health (Unisanté), University of Lausanne
- Adolfo Correa
- Department of Medicine, University of Mississippi Medical Center
- Simon R. Cox
- Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh
- Graciela E. Delgado
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University
- Kai-Uwe Eckardt
- Department of Nephrology and Hypertension, University of Erlangen-Nürnberg
- Arif B. Ekici
- Institute of Human Genetics, Friedrich-Alexander-UniversitätErlangen-Nürnberg
- Karlhans Endlich
- Department of Anatomy and Cell Biology, University Medicine Greifswald
- James S. Floyd
- Department of Medicine, University of Washington
- Eliza Fraszczyk
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Xu Gao
- Laboratory of Environmental Precision Health, Mailman School of Public Health, Columbia University
- Xīn Gào
- German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research
- Allan C. Gelber
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Mohsen Ghanbari
- Department of Epidemiology, Erasmus University Medical Center
- Sahar Ghasemi
- Department of Psychiatry and Psychotherapy, University Medicine Greifswald
- Christian Gieger
- Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Philip Greenland
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Megan L. Grove
- Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Sarah E. Harris
- Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh
- Gibran Hemani
- MRC Integrative Epidemiology Unit, University of Bristol
- Peter Henneman
- Department of Clinical Genetics, Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Centres, University of Amsterdam
- Christian Herder
- Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf
- Steve Horvath
- Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles
- Lifang Hou
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Mikko A. Hurme
- Department of Microbiology and Immunology, Faculty of Medicine and Health Technology, Tampere University
- Shih-Jen Hwang
- Framingham Heart Study
- Sharon L. R. Kardia
- Department of Epidemiology, School of Public Health, University of Michigan
- Silva Kasela
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- Marcus E. Kleber
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University
- Wolfgang Koenig
- Deutsches Herzzentrum München, Technische Universität München
- Jaspal S. Kooner
- National Heart and Lung Institute, Imperial College London
- Florian Kronenberg
- Institute of Genetic Epidemiology, Medical University of Innsbruck
- Brigitte Kühnel
- Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Christine Ladd-Acosta
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Terho Lehtimäki
- Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University
- Lars Lind
- Department of Medical Sciences, Uppsala University
- Dan Liu
- Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE)
- Donald M. Lloyd-Jones
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Stefan Lorkowski
- Institute of Nutritional Sciences, Friedrich Schiller University Jena
- Ake T. Lu
- Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles
- Riccardo E. Marioni
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
- Winfried März
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University
- Daniel L. McCartney
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh
- Karlijn A. C. Meeks
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Lili Milani
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- Pashupati P. Mishra
- Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University
- Matthias Nauck
- DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald
- Christoph Nowak
- Department of Neurobiology, Care Sciences and Society (NVS), Family Medicine and Primary Care Unit, Karolinska Institutet
- Annette Peters
- Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Holger Prokisch
- Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München
- Bruce M. Psaty
- Department of Medicine, University of Washington
- Olli T. Raitakari
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
- Scott M. Ratliff
- Department of Epidemiology, School of Public Health, University of Michigan
- Alex P. Reiner
- Department of Epidemiology, University of Washington
- Ben Schöttker
- German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research
- Joel Schwartz
- Department of Environmental Health, Harvard T.H. Chan School of Public Health
- Sanaz Sedaghat
- Division of Epidemiology and Community Health, School of Public Health, University of Minnesota
- Jennifer A. Smith
- Department of Epidemiology, School of Public Health, University of Michigan
- Nona Sotoodehnia
- Cardiovascular Health Research Unit, University of Washington
- Hannah R. Stocker
- German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research
- Silvia Stringhini
- Center for Primary Care and Public Health (Unisanté), University of Lausanne
- Johan Sundström
- Department of Medical Sciences, Uppsala University
- Brenton R. Swenson
- Cardiovascular Health Research Unit, University of Washington
- Joyce B. J. van Meurs
- Department of Internal Medicine, Erasmus Medical Center
- Jana V. van Vliet-Ostaptchouk
- Department of Endocrinology, University of Groningen, University Medical Center Groningen
- Andrea Venema
- Department of Clinical Genetics, Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Centres, University of Amsterdam
- Uwe Völker
- DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald
- Juliane Winkelmann
- Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München
- Bruce H. R. Wolffenbuttel
- Department of Endocrinology, University of Groningen, University Medical Center Groningen
- Wei Zhao
- Department of Epidemiology, School of Public Health, University of Michigan
- Yinan Zheng
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- The Estonian Biobank Research Team
- The Genetics of DNA Methylation Consortium
- Marie Loh
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Harold Snieder
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Melanie Waldenberger
- Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Daniel Levy
- Framingham Heart Study
- Shreeram Akilesh
- Department of Laboratory Medicine and Pathology, University of Washington
- Owen M. Woodward
- Department of Physiology, University of Maryland School of Medicine
- Katalin Susztak
- Department of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine
- Alexander Teumer
- DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald
- Anna Köttgen
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- DOI
- https://doi.org/10.1038/s41467-021-27198-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Serum urate concentration can be studied in large datasets to find genetic and epigenetic loci that may be related to cardiometabolic traits. Here the authors identify and replicate 100 urate-associated CpGs, which provide insights into urate GWAS loci and shared CpGs of urate and cardiometabolic traits.
