Upper gut heat shock proteins HSP70 and GRP78 promote insulin resistance, hyperglycemia, and non-alcoholic steatohepatitis

Giulia Angelini; Lidia Castagneto-Gissey; Serenella Salinari; Alessandro Bertuzzi; Danila Anello; Meenakshi Pradhan; Marlen Zschätzsch; Paul Ritter; Carel W. Le Roux; Francesco Rubino; Nicola Basso; Giovanni Casella; Stefan R. Bornstein; Valentina Tremaroli; Geltrude Mingrone

doi:10.1038/s41467-022-35310-5

Nature Communications (Dec 2022)

Upper gut heat shock proteins HSP70 and GRP78 promote insulin resistance, hyperglycemia, and non-alcoholic steatohepatitis

Giulia Angelini,
Lidia Castagneto-Gissey,
Serenella Salinari,
Alessandro Bertuzzi,
Danila Anello,
Meenakshi Pradhan,
Marlen Zschätzsch,
Paul Ritter,
Carel W. Le Roux,
Francesco Rubino,
Nicola Basso,
Giovanni Casella,
Stefan R. Bornstein,
Valentina Tremaroli,
Geltrude Mingrone

Affiliations

Giulia Angelini: Università Cattolica del Sacro Cuore
Lidia Castagneto-Gissey: Department of Surgical Sciences, Sapienza University of Rome
Serenella Salinari: Department of Computer, Control, and Management Engineering “Antonio Ruberti”, University of Rome “Sapienza”
Alessandro Bertuzzi: CNR-Institute of Systems Analysis and Computer Science (IASI)
Danila Anello: Università Cattolica del Sacro Cuore
Meenakshi Pradhan: Wallenberg Laboratory for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, University of Gothenburg
Marlen Zschätzsch: Institute of Natural Materials Technology, Faculty of Mechanical Science and Engineering, Technischen Universität Dresden
Paul Ritter: Bruker Daltonics SPR
Carel W. Le Roux: Diabetes Complications Research Centre, Conway Institute, University College Dublin
Francesco Rubino: Bariatric and Metabolic Surgery; King’s College Hospital
Nicola Basso: Department of Surgical Sciences, Sapienza University of Rome
Giovanni Casella: Department of Surgical Sciences, Sapienza University of Rome
Stefan R. Bornstein: Department of Medicine III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden
Valentina Tremaroli: Wallenberg Laboratory for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, University of Gothenburg
Geltrude Mingrone: Università Cattolica del Sacro Cuore

DOI: https://doi.org/10.1038/s41467-022-35310-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 21

Abstract

Read online

High-fat diet (HFD) increases the risk of insulin resistance and non-alcoholic steatohepatitis (NASH). Here the authors report that the heat shock proteins HSP70 and GRP78 are increased in the jejunum of rats on HFD, and their continuous infusion leads insulin resistance and NASH, while in rats on a high-fat diet infused with monoclonal antibodies against HSP70 and GRP78 these phenotypes are reversed.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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