Nature Communications (Oct 2020)
AKT-induced lncRNA VAL promotes EMT-independent metastasis through diminishing Trim16-dependent Vimentin degradation
- Han Tian,
- Rong Lian,
- Yun Li,
- Chenying Liu,
- Shujun Liang,
- Wei Li,
- Tianyu Tao,
- Xingui Wu,
- Yaokai Ye,
- Xia Yang,
- Jian Han,
- Xuwei Chen,
- Jun Li,
- Yukai He,
- Mengfeng Li,
- Jueheng Wu,
- Junchao Cai
Affiliations
- Han Tian
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University
- Rong Lian
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University
- Yun Li
- Institute of Tissue Transplantation and Immunology, Department of Immunobiology, Jinan University
- Chenying Liu
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University
- Shujun Liang
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University
- Wei Li
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University
- Tianyu Tao
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University
- Xingui Wu
- Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University
- Yaokai Ye
- Clinical Medicine, Zhongshan School of Medicine, Sun Yat-sen University
- Xia Yang
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University
- Jian Han
- Cancer Institute, Southern Medical University
- Xuwei Chen
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University
- Jun Li
- Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University
- Yukai He
- Department of Medicine and Georgia Cancer Center, Medical College of Georgia, Augusta University
- Mengfeng Li
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University
- Jueheng Wu
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University
- Junchao Cai
- Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University
- DOI
- https://doi.org/10.1038/s41467-020-18929-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
The role of long non-coding RNA (lncRNA) in AKT-driven tumor development is unclear. Here, the authors identify VAL (Vimentin associated lncRNA) to be directly induced by AKT/STAT3 signaling and report a lncRNA-mediated mechanism for active AKT-driven EMT-independent lung adenocarcinoma metastasis.
