WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling

Marte Sneeggen; Nina Marie Pedersen; Coen Campsteijn; Ellen Margrethe Haugsten; Harald Stenmark; Kay Oliver Schink

doi:10.1038/s41467-019-10794-w

Nature Communications (Jun 2019)

WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling

Marte Sneeggen,
Nina Marie Pedersen,
Coen Campsteijn,
Ellen Margrethe Haugsten,
Harald Stenmark,
Kay Oliver Schink

Affiliations

Marte Sneeggen: Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
Nina Marie Pedersen: Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
Coen Campsteijn: Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
Ellen Margrethe Haugsten: Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
Harald Stenmark: Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
Kay Oliver Schink: Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo

DOI: https://doi.org/10.1038/s41467-019-10794-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 20

Abstract

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WDFY2 is known as a tumour suppressor but its function is unclear. Here, the authors show that WDFY2 interacts with the v-SNARE VAMP3, leading to a suppression of the metalloprotease MT1-MMP secretion, suggesting that WDFY2 acts a tumour suppressor by suppressing MT1-MMP secretion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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